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Life Unplugged by Bhavya Sharma. Paperback1st Editionpages. Published December 31st by Expression Publications. To see what your friends thought of this book, please sign up. To ask other readers questions about Life Unpluggedplease sign up.
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Jul 19, Keshav rated it did not like it. The author wants to appear as this cool-wannabe hipster who bhagya poor grammar. He has notions regarding smart, educated, fluent teens who have a name in their schools. The only part I liked was when the male lead gets to sit with his crush in the school auditorium and how he creepily describes his perverted thoughts and then the overly dramatic first kiss.
The author should realise that the manner in which people speak and how their conversations are to be narra The author wants to appear as this cool-wannabe hipster who uses poor grammar. The author should realise that the manner in which people speak and how their conversations are to be narrated are two different things.
life unplugged bhavya sharma
Those cut short slangs, bad grammar, poor editing made me wonder ‘Why would someone do such a thing to a wonderful book title?
Sep 08, Sohit rated it did not like ynplugged.
Easily one of the worst books of the decade by an Indian author. Very kiddish naration and far too many cuss words, cannot find one reason to recommend this book.
Please stay away from this book. Waste of time, money and paper. Nov 02, Sharad Kaplingad rated it did not like it. For those who like good books, I request you to stay away from this book. I can clearly say this is the worst piece of literature, I have come across. Bad grammar, poor edit Spelling mistakes are a frequent scene and immature story. Jithesh Patel rated it really liked it May 25, Jyothsna rated it liked it Aug 05, Divyanshu Kumra rated it did not like it May 15, Ishana rated it liked it Jul 06, Abhilash Ruhela rated it it was ok Jan 12, Mayur sarda rated it it was ok Jul 14, Amal Dave rated it it was ok May 04, Kunal Thakur rated it it was ok Feb 21, Aditya Kumar rated it really liked it Jan 21, Apoorv rated it really liked it Jan 27, Twinkle Jain rated it it was amazing May 16, Alsha rated it liked it Sep 02, Kalicharan rated it it was amazing Sep 29, Shatakshi Dubey rated it liked it Jan 05, Manisha Kumaran rated it liked it Dec 22, Rahul Rocky rated it really liked it Aug 16, Ashlee Anderson rated it did not like it Nov 14, Yash Shah rated it liked it Jun 30, Rachita Pradhan rated it it was ok Jul 25, Prabhat Chaurasia rated it it was ok Nov 04, Shreya Chaudhury rated it it was amazing Jun 24, Mukul Negi rated it it was ok Sep 02, Hothal Patel rated it did not like it Jan 22, Krishna Kiran rated it did not like it Mar 05, Jaishree Baid rated it it was ok Jun 18, There are no discussion topics on this book yet.
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Tabak F., Akut Hepatitler İ.Ü. Vol. pp. 43– (Cerrahpaşa Tıp Fakültesi Sürekli Tıp Eğitimi Etkinlikleri Hepato-Bilier Sistem ve Pankreas Hastalıkları. Amaç: Günümüzde viral hepatitler ve HIV enfeksiyonu önemli küresel bağlı olarak akut veya kronik hepatitler gelişebilmekte ve sonuçta. Mıstık R. Akut viral hepatitler. Memik F editor. Klinik Gastroenter- oloji. Bursa: Nobel ve Güneş Kitabevi; p Modahi LE, Lai MM. Hepatitis delta .
Cesitli cografi bolgelerde, etyolojisi degisiklik gosterebilmektedir. Bati dunyasinda, Hep B insidansi duraklasa da, alinan goclerle, insidansin tekrar artacagi on gorulmektedir.
Karaciger Naklinin, endikasyonlari ve karsi endikasyonlari tarsilmis ve Karaciger Yogun Bakim Unitesinde uyulmasi gereken yeni yontemlerden soz edilmistir. It can be due to various different etiologies in different geographic areas of the globe.
Especially the incidence of Hep B is anticipated to increase in western world after a period of plateau, due to increasing immigration from developing countries. Indications and contraindications of liver transplantation discussed as well as the current Intensive Care Unit management guidelines.
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A case of acute hepatitis following mad honey ingestion
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A case of acute hepatitis following mad honey ingestion
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Viral Hepatitler ve Akut Karaciğer Yetmezliği | Article | Türkiye Klinikleri
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Please share the subjects you think may enrich our website or if there is any problem regarding our website. ABSTRACT Acute Liver Failure presents in patients in the absence of any previously known liver disease, presenting with liver injury and diminished sustainability of the hepatic functions.
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Welcome to Weekly Dirt, the best place on the Internet for off-road news from around the world. Taking his fifth consecutive overall win, the ‘Moose’ was in top form enjoying the technical course and perfect weather conditions. The John Penton Story PJPS is currently in post-production and has a new theatrical distribution partnership with Gathr Films in Los Angeles, which means it will be shown in select theaters around the country. According to PDM, PJPS’ loyal followers will use social media and grassroots efforts to spread the word and “evangelize” the screenings in their towns among friends, family, the community and the motorcycle industry to pre-book the local theatre for special screenings of PJPS.
Gathr Films has relationships with theatres all across the United States. Powerdear includes the big commercial theatre chains as well as independent art houses. Gathr can also facilitate screenings in a wide array of venues such as libraries or community centers, all you need are seats and digital projection capabilities.
It is then up to the fans to spread the word about the event!
Motorcycle enthusiasts and movie fans alike kt simply go to the website to bring the amazing story of John Penton’s passion and influence to their local theatre. To become a Captain or get notified about screenings near you please visit: After struggling with his privateer Honda program inthe former world and British off-road champ has signed with Sherco for the coming year.
Check out a video interview with Knighter about his plans: After all, Pfeiffer did win Erzberg a few times! The Catalina Grand Prix has officially been cancelled for While the city has run other events, of course, dirt bike races are another matter—as the city discovered. But while one race seems to be history, another appears on the horizon. SCORE reportedly plans to introduce a new race to the series next year and hold it on this side of the border near El Centro, California.
Tentatively scheduled for Aprilthe race will include all SCORE classes including bikes and ATVs, though those may run on a separate day from the trucks and cars.
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Like most racers going overseas, he had some last-minute personal-preference items with him as checked luggage, including extra suspension units. Much to his chagrin, however, TSA agents refused to let the fork legs and shock pass inspection—and Club team rider Ryan Kudla found himself in the same boat. Photo by Adam Booth.
Photo by Chris Denison. On a motocross track, the Flux and Phase gear combos—built on popular Thor gear chassis—work every bit as well as powerwwear expected them to, and the style ktn all the products is very cool for the strictly-KTM customer.
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The gear performed well there, with the high-altitudes proving to be a great testing ground for the multi-layered jacket. Powerear updated HJC logo can be found on the visor, chin guard and back of each new helmet.
Photo by Sean Klinger. If you only look at the off-road motorcycle scene, HJC Helmets powerwer not even be on your radar as far as helmets go, yet since HJC has been one of the top helmet brands in the United States.
The company has a long and focused history of making helmets at every price point to meet the needs of professional racers and first-timers alike. For a sub-two-hundred-dollar helmet, the FG-X has impressive features and new designs that are hard to ignore.
View the discussion thread.
NOW ONLINE: KTM’S Motocross World In Form Of The SX Digital Folder
Skip to main content. Follow us email facebook twitter instagram Google Plus youTube rss. The John Penton Story will be in select theaters soon. Photo By Paul Powerwrar. David Knight has forsaken his Honda and is now a part of the Sherco team.
Book Source: Digital Library of India Item : Vadivelu : Sachidhanandham Printing. Book Source: Digital Library of India Item : Sri Koviloor Ponnampala : National. I have downloaded a book named KAIVALYA NAVANEETHAM (Barcode is ) attached KaivalyaNavaneetham eng version.
Links News Ways to Help. Bookseller Locator Bookseller Trade. Sri Karapatra Swami Tandavaraya Swami.
Kaivalya Navaneeta Translated By Swami Ramanananda Saraswathi
Our ordering system is being updated. Sri Karapatra Swami was a monk and teacher Pithadhipati at the sacred seat of learning at Kashi also known as Varanasi or Benares. Kaialya is widely considered to be the easiest to understand summary of the teachings of Advaita Vedanta, and was often recommended by Sri Ramana Maharshi to those wanting a clearer understanding of these teachings. Don’t have a World Wisdom ID?
Online Library of Articles. Video Clips on his Early Spiritual Influences. Who was Charles Eastman Ohiyesa?
Interview with Frithjof Schuon – on Spirituality. Noble Faces, Strong Voices: Exploring “The Spirit of Indian Women”.
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Englixh is the Sun Dance Religion? The Sacred Worlds Series. Insights into the early Christian Desert Fathers and Mothers. Interview with Frithjof Schuon – on Primordiality.
Click cover for larger image. Eastern Religion Hinduism Metaphysics.
Description Two short classics of Advaita Vedanta presented in a single volume: The Lamp of Non-Dual Knowledge is in the form of a dialogue between a seeker and his spiritual master, with the seeker posing nnavaneetham probing questions about the nature of existence, the universe, and humankind.
Of course, these fundamental questions still puzzle people, and so these clear answers from the ancient past often strike home with readers today. It is a widely known Advaita classic. The Cream of Liberation outlines the basic philosophical principles of Advaita Vedanta and reviews these in a way intended to engllsh them very clear to readers, again in the form of a dialogue between a master and devotee.
Kaivalya Navaneeta  – Rs/- : Sri Ramanashram bookstore, The Art of E-commerce
Both of these books were admired by Sri Ramana Maharshi, and were recommended to those wanting to understand the non-dualistic spiritual path of Advaita Vedanta. Bringing these two short texts together in a single volume offers the reader the opportunity to grasp fundamental concepts of Advaita Vedanta within the evocative setting of ancient sages instructing their disciples on questions that still intrigue people today.
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A Blackjack Bargainer. Primary view of object titled ‘A Blackjack Bargainer’. Thumbnail image of item number 1 in: ‘A Blackjack Bargainer’. A Blackjack Bargainer. O Henry. The most disreputable thing in Yancey Goree’s law office was Goree himself, sprawled in his creakv old arm- chair. The rickety. Read A Blackjack Bargainer by O Henry for free at Read Print.
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A Blackjack Bargainer–O. Henry ()
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Henry was a prolific American short-story writer – a master of surprise endings – who wrote about the life of ordinary people in New York City. Blackjak is “A Blackjack Bargainer,” the story of the drunken Yancey Goree, a washed-up lawyer who has lost his money, possessions, bargainwr, and self-respect as a result of playing poker. After settling a feud, however, he manages O. After settling a feud, however, he manages to redeem himself by trading places with an old rival.
Proceeds from sale of this title go to Reach Out and Read, an innovative literacy advocacy organization. Published December 12th by Blackstone Audio, Inc. bargaineg
To see what your friends thought of this book, please sign up. To ask other readers questions about A Blackjack Bargainerplease sign up. Be the first to ask a question about A Blackjack Bargainer. Lists with This Book. This book is not yet featured on Listopia. Jun 26, Leah Markum rated it did not like it Batgainer The story takes a while to set up.
Yancy Goree is the last bargauner on his side of the family, a family with a classic, back-country feud with another family in town that happens to have one surviving male member. Goree has also blakjack his share of bad luck with gambling and having a sore ego. Eventually the plot kicks in and has a last minute twist, which apparently is the author’s trademark.
I didn’t see any particular meaning to the story or characters I gained significant perspective from. It’s mo The story takes a while to set up. It’s mostly old-school soap opera.
Jul 06, Pallavi Kamat rated it liked it. A simple story stretched unnecessarily. Two old friends end their bargaiber – the end obviously has a twist! Aug 15, K. Anna Hardy rated it liked it.
A Blackjack Bargainer
I have arranged my thoughts into a haiku: Sarah rated it liked it Aug 15, Tonia rated it liked it Oct 22, Robin Gipson rated it liked it Jun 06, Michael Sorbello rated it liked it Jul 26, Akje rated it really liked it Jan 25, Michael Lloyd-Billington rated it liked it Sep 14, Angie rated it it was ok Feb 20, Hanane rated it liked it Sep 30, Sarah Gray rated it it was ok Oct 22, Questioner rated it it was ok Feb 20, Chitraksh Ashray rated it it was ok Dec 17, Mishiko Nikoleishvili rated it liked it Feb 10, Kinshuk Gupta rated it really liked it Oct 23, Leah marked it as to-read Oct 30, Ni-march marked it as to-read May 14, Mark Ennis added it Apr 16, Akshaya Jayadevan added it Jun 19, Etika Rohma added it Apr 03, Maria Barseghyan added it Jun 28, Sidharth Vardhan added it Jul 21, Bibliophile added it Nov 30, Lisa Finefrock marked it as to-read Jun 30, Boyd added it Nov 09, Abe added it Nov 24, There are no discussion topics on this book yet.
William Sydney Porter lends the pen name “O. Henry” to surprise endings signed officially as Sydney Porter. His biography shows where he found inspiration for his characters. Their voices and his language were products of his era. He was born Greensboro, North Carolina. When he was three years old, his mother died from tuberculosis. He left school at fifteen, worked five years in his uncle’s d William Sydney Porter lends the pen name “O.
A Blackjack Bargainer by O. Henry
He left school at fifteen, worked five years in his uncle’s drugstore, then for two years at a Texas sheep ranch. In he went to Austin where he worked in a real estate office, a church choir, and spent four years as a draftsman in the General Land Office.
His wife and firstborn died, but daughter Margaret survived him. After he failed barvainer establish a small humorous weekly, he worked in poorly-run bank. When its accounts did bargalner balance, he was blamed for it, and fired.
In Houston, he worked for a few years until — ordered to stand trial for embezzlement — he fled to New Orleans and thence, to Honduras. Two years later, he returned on account of his wife’s illness. Apprehended, Porter served a few months more than three years in a Penitentiary in Columbus, Ohio. While in Pittsburgh, Pennsylvania, he sent manuscripts to New York editors.
In the spring ofAinslee’s Magazine bargakner him a regular income if he moved to New York. In less than eight years, he became a bestselling author of collections of short stories.
Others were rewarded financially more. Many stories have been made into films. Trivia About A Blackjack Barga No trivia or quizzes yet. Just a moment while we sign you in to your Goodreads account.
Correlations between in vitro and in vivo data (IVIVC) are often used during pharmaceutical development in order to reduce development time and optimize the. This presentation gives a bird’s eye view on Dissolution in context with IVIVC. It discusses various levels of Correlations currently in practice. Invitro Invivo study & their correlation shortens the drug development period, economizes the resources and leads to improved product quality. Increased activity.
October 06, ; Accepted Date: December 31, ; Published Date: A Strategic Tool in Drug Development. J Bioequiv Availab S3. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the correlation author and source are credited. In vitro in vivo correlations IVIVC play a key role in the drug development and optimization of formulation which is iviiv a time consuming and expensive process.
Formulation optimization requires alteration in formulation, composition, equipments, batch sizes and manufacturing process. If such types of one or more changes are applied to the formulation, the in vivo bioequivalence studies in human may required to be done to prove the similarity of the new formulation which will not only increase the burden of carrying out a number of bioequivalence studies but eventually increase the cost of correlatoon optimization process and ultimately marketing of the new formulation.
To overcome these problems it is desirable to develop in vitro tests that reflect can bioavailability data. IVIVC can be used in the development of new pharmaceuticals to reduce the number of human studies during the formulation development. Thus, the main objective of xorrelation IVIVC is to serve as a surrogate for in vivo bioavailability and to support biowaivers.
In vitro – in vivo correlation: from theory to applications.
IVIVC is a mathematical relationship between in vitro properties of a dosage form with its in vivo performance. The In vitro release data of a dosage form containing the active substance serve as characteristic in vitro property, while the In vivo performance is generally represented by the time course of the plasma concentration of clrrelation active substance.
For oral dosage forms, the in vitro release is usually measured and considered as dissolution rate. The relationship between the in vitro and in vivo characteristics can be expressed mathematically by a linear or nonlinear correlation. However, correlatlon plasma concentration ivib be directly correlated to the in vitro release rate; it has to be converted to the in vivo release or absorption data, either by pharmacokinetic compartment model analysis or by linear system analysis [ 1 ].
The establishment of a rational relationship correlatkon a biological property, or a parameter derived from a biological property produced by a dosage form, and a physicochemical property or characteristic of the same dosage form [ 2 ].
Generally, the In vitro property is the rate or extent of drug dissolution or release while the In vivo response is the plasma drug concentration correoation amount of drug absorbed. Practically, the purpose of IVIVC is to use drug dissolution results from two or more products to predict similarity or dissimilarity of expected plasma drug concentration profiles. Before one considers relating in vitro results to in vivo, one has to establish as to how one will establish similarity or dissimilarity of in vivo response i.
The methodology of establishing similarity or dissimilarity of plasma drug concentrations profile is commonly known as bioequivalence correlstion. There are very well established guidances and standards available for establishing bioequivalence between drug profiles and products [ 3 ].
The optimization of formulations may require changes in the composition, manufacturing process, equipment, and batch sizes. IVIVC is often adequate for justification of therapeutically meaningful release specifications of the formulation. Scale up post approval changes Time and cost saving during the product development. Validated IVIVC is also serves as justification for a biowaivers in filings of a Level 3 or Type II in Europe variation, either during scaleup or post approval, as well as for line extensions e.
The main purpose of an IVIVC model to utilize in vitro dissolution profiles as a surrogate for in vivo bioequivalence and to support biowaivers. The concept of correlation level is based upon the ability of the correlation to reflect the complete plasma drug level-time profile which will result from administration of the given dosage form.
This level of correlation is the highest category of correlation and represents a point-to-point relationship between in vitro dissolution rate and in vivo input rate of the drug from the dosage form [ 35 ]. Level A correlation is the most preferred to achieve; since it allows bio waiver for changes in manufacturing site, raw material suppliers, and minor changes in formulation.
The purpose of Level A correlation is to define a direct relationship between in vivo data such that measurement of in vitro dissolution rate alone is sufficient to determine the biopharmaceutical rate of the dosage form.
In this level of correlation, the mean in vitro dissolution time MDT vitro of the product is compared to either mean in vivo residence time MRT or the mean in vivo dissolution time MDTvivo. A level B correlation does not uniquely reflect the actual in vivo plasma level curves, also in vitro data from such a correlation could not be used to justify the extremes of quality control standards hence it is least useful for regulatory purposes [ 5 ].
This is the weakest level of correlation as partial relationship between absorption and dissolution is established since it does not reflect the complete shape of plasma drug concentration time curve, which is the critical factor that defines the performance of a drug product. Due to its obvious limitations, the usefulness of a Level C correlation is limited in predicting in vivo drug performance.
In the early stages of formulation development Level C correlations can be useful when pilot formulations are being selected while waiver of an in vivo bioequivalance study biowaiver is generally not possible [ 56 ]. This level refers to the relationship between one or more pharmacokinetic parameters of interest C maxAUC, or any other suitable parameters and amount of drug dissolved at several time point of dissolution profile. Multiple point level C correlation may be used to justify a biowaivers provided that the correlation has been established over the entire dissolution profile with one or more pharmacokinetic parameters of interest.
A multiple Level C correlation should be based on at least three dissolution time points covering the early, middle, and late stages of the dissolution profile. The development of a level A correlation is also likely, when multiple level C correlation is achieved at each time point at the same parameter such that the effect on the in vivo performance of any change in dissolution can be assessed [ 56 ].
It is not a formal correlation but it is a semi quantitative qualitative analysis and rank order correlation and is not considered useful for regulatory purpose but can be serves as an aid in the development of a formulation or processing procedure [ 57 ] Table 1. It is generally assumed that absorption and dissolution have a linear relationship hence dissolution and absorption characteristics of a drug are commonly shown interchangeably.
Thus from Figure 2it is to be noted that one should be able to establish drug profiles with dissolution profiles combined with the pharmacokinetic characteristics of the drug as describe in the example above. This process of obtaining a drug profile from dissolution results is known as convolution.
The opposite of this, i. Schematic representation of deconvolution and convolution processes. Convolution is the process of combined effect of dissolution and elimination of drug in the body to reflect blood drug concentration-time profile right to left. On the other hand, extracting dissolution profiles from blood drug concentration-time profile is known as the deconvolution process left to right . In mathematical terminology, dissolution results become an input function and plasma concentrations e.
Using the NONMEM package, a nonlinear mixed effects model can be fitted to the data with a time-scale model linking the in correlafion and in vivo components [ 10 ]. It has been demonstrates that the convolution based and differential equation based models can be mathematically equivalent [ 11 ]. Correlatoon has been developed which implements a differential equation based approach.
This method utilises existing NONMEM libraries and is an accurate method of modeling which is far more straightforward for users to implement. This research shows that, when the system being modeled is linear, the use of differential equations will produce results that are practically identical to those obtained from the convolution method.
But is a task that can be time consuming and complex [ 12 ]. As a result, this methodology, despite its advantages over the deconvolutionbased approach, is not in widespread use. The relationship between jviv quantities in vitro release and plasma drug concentrations is modeled directly in a single stage rather than via an indirect two stage approach.
The model directly predicts the plasma concentration time course. As a result the modeling focuses on the ability to predict measured quantities not indirectly calculated quantities such as the cumulative amount absorbed. The results are more readily interpreted in terms of the effect of in vitro release on conventional bioequivalence metrics [ 5 ].
Deconvolution is a numerical method used to estimate the time course of drug input using a mathematical model based on the convolution integral. The deconvolution technique requires the comparison of in vivo dissolution profile which can be obtained from the blood profiles with in vitro dissolution profiles. The observed fraction of the drug absorbed is estimated based on the Wagner-Nelson method. IV, IR or oral solution are attempted as the reference.
Then, the pharmacokinetic parameters are estimated using a nonlinear regression tool or obtained from literatures reported previously. Based on the IVIVC model, the predicted fraction of the drug absorbed is calculated ivic the observed fraction of the drug dissolved. It is the most commonly cited and used method in the literature [ 10 ]. However this approach is conceptually difficult to use. Even when in vivo dissolution curves are obtained there is no parameter available with associated statistical confidence and physiological relevance, which corrrelation be used to establish the similarity or dissimilarity of the curves [ 13 ].
A more serious limitation of this approach is that it often requires multiple products having potentially different in vivo release characteristics slow, medium, fast.
These products are then ivuv to define experimental conditions medium, apparatus etc. Another approach, has been proposed is based on systems of differential equations [ 15 ]. The use of a differential equation based model could also allow for the possibility of accurately modelling nonlinear systems and further investigation is being carried out into the case where the drug is eliminated by a nonlinear, saturable process.
The convolution and deconvolution methods assume that the system being modelled is linear but, in practice, this is not always the case. Work to date has shown that the convolution-based method is superior, but when presented with nonlinear data even this approach will crrelation. It is expected that, in the nonlinear case, the use of a differential equation based method would lead to more accurate predictions of plasma concentration.
The incorporation of time-scaling in the PDx-IVIVC equation allows this parameter to be estimated directly from the in vivoand vitro release data. As a result, the predictability of an IVIVC model can be evaluated over the entire in vivo time course.
For orally administered drugs, IVIVC is expected for highly permeable drugs, or drugs under dissolution rate-limiting conditions, which is supported by the Biopharmaceutical Classification System BCS [ 616 ]. For extended-release formulations following oral administration, modified BCS containing the three classes high aqueous solubility, low aqueous solubility, and variable solubility is proposed [ 17 ].
In vitro – in vivo correlation: from theory to applications.
Any well designed and scientifically sound approach would be acceptable for establishment of an IVIVC. For the development and validation of a IVIVC model, two or three different formulations with different release rates, such as slow, medium, fast should be studied In vitro oviv In vivo [ 6 ].
A number of products with different release rates are usually manufactured by varying the primary rate controlling variable e. To develop a discriminative in vitro correltaion method, several method variables together with formulation variables are studied, e.
Essentially at this stage a level A correlation is assumed and the formulation strategy is initiated with the objective of achieving the iiv in vitro profile. In context of understanding the applications of IVIVR throughout the product development cycle, it is useful to become familiar with the following terms as they relate to a typical product development cycle for oral extended-release product [ 5 ].
An assumed IVIVC is the one that provides the initial guidance and direction for the uviv formulation development activity. Thus, during step 1 and with a particular desired product, appropriate in vitro targets are established to meet the desired in vivo profile specification.
This assumed model can be the subject of revision as prototype formulations are developed and characterized in vivo, with the results often leading to a further cycle of prototype formulation and In vivo characterization. Out of this product development cycle and In vivo characterization and, of course, extensive in vitro testing is often correlatjon what correlztion be referred to as retrospective IVIVC. The defined formulation that meets the in vivo specification is employed for Stage 2.
At this stage based on a greater understanding and appreciation of defined formulation and its characteristics, a prospective IVIVC is established through a well defined prospective IVIVC study [ 185 ]. In the first step, the In vivo input profile of the drug from different formulations is calculated from drug concentrations in plasma Figure correaltion.
Providing the pharmaceutical industry with oral drug development tools –
Certainly, step 1 activity should culminate in correlztion pilot PK study. This is typically a four or five-arm cross-over study. The size of this pilot pharmacokinetic study will vary depending on the inherent variability of the drug itself but typically range from 6 to 10 subjects [ 5 ]. To separate drug input from drug distribution and elimination, model-dependent approaches, such as Wagner- Nelson and Loo-Riegelman, or model independent procedures, based on numerical deconvolution, may be utilised ckrrelation 192021 ].
In the model dependent approaches, the distribution and elimination rate constants describe pharmacokinetics after absorption. In the numerical deconvolution approach, the drug unit impulse response function describes distribution and elimination phases, respectively.
RELIGIOSITAS DAN PRESTASI OLAHRAGA PADA ATLET Makalah disampaikan Abduljabar B. Pedagogi olahraga:konsep dan. ringkasan buku, membuat makalah, dan diskusi kelompok dengan .. guru yaitu, kompetensi profesional, pedagogik, kepribadian dan perkembangan ilmu pengetahuan, teknologi, seni, dan budaya dan/atau olah raga. didalam pendekatan pedagogi pembelajaran dan pengajaran di dunia,tidak . bertanggung jawab, serta 3 jenis olahraga yang dianjurkan Rasulullah SAW Makalah ini akan memfokuskan kelebihan dan kekurangan penataan ruang.
Skip to main content. Log In Sign Up. Membina semula persekitaran pembelajaran diluar kelas yang mampan dari pemahaman rekabentuk dan pendekatan-pendekatan sekolah alam di Indonesia, 1st International Symposium on Conducive Learning Environment for Smart School CLES ’11 Developing an institution with a holistic Conducive Learning Environment in mind is not easy.
The development of the learning environment should be examined in terms of the environment, master planning, space planning and design elements as well as operating assets and buildings.
This will create a school which takes into account the overall environment and ensure the health interests and excellent well being of its students. It intends to uphold and generate the development of knowledge in conducive learning environment for Malaysia and the world. The conference itself tries to gather and share different view and understanding of studies and research among academician, architect, consultants, developers, engineers, government officer, local authorities, manufacturers, politicians, project manager, students, surveyors and all those interested in one day seminar and conference in order to: To provide formal communication platform and publication to the members of the international researchers who have aspiration about Smart School.
To disseminate knowledge that related with the development of learning environment for smart school to the local and overseas research community. To empower the research collaboration between members of the group with another researchers within and outside UKM. Empowering the research network for smart school with the local and overseas universities. The study highlights the key components of PRIME and underscores the causes of variations that may occur in both the design and construction stages in the school building projects.
The effects of the variations made in the PRIME school building projects will be presented, together with a checklist of the corresponding controls to manage these variations that may occur during the: Finally, the paper will present the most important causes, their frequent effects and effective controls for managing change orders in the PRIME school building projects in Singapore.
They usually have long duration, various uncertainties, and complex relationships among the participants. The need to make changes in a construction project is a matter of practical reality. The high living standards have generated many manufacturing and building employment opportunities in global construction industry.
The growth of towns has accelerated as a result of high population growth.
Large and complex projects have been built, attracting contractors from all over the world. Most of these contractors appear to lack a sufficient understanding of the social, cultural and physical environment Dulaimi and Hwa, This situation, coupled with inexperienced maka,ah, has led to inadequate designs resulting in many changes to plans, specifications and contract terms. Changes are inevitable in any construction project Mokhtar, et makaalah.
Needs of the owner may change in the course of design or construction, market conditions may impose changes to the parameters of the project, and technological developments may alter the design and the choice of the engineer. Furthermore, errors and omissions in engineering or construction may force a change. All these factors and many others necessitate changes that are costly and generally un-welcomed by all parties. Contractual provision is required to define the conduct of owner, consultant and contractor to participate in and manage changes.
Systematic and proper procedures must be set in place to process a change from conceptual development until it materializes in the field.
The reality is that an adverse environment exists among parties in the construction industry. Changes could be perceived mamalah positive or negative to the preconceived goals of the professionals involved in a project.
Therefore, a major change must be managed and handled professionally in order to minimize its cost, schedule and consequential impacts that may divert the project away from its targeted goals. To identify and analyze potential changes that could happen in a project as early as possible can enhance the management of projects. Learning from these changes is imperative because the professionals can improve and apply their experience in the future. For this purpose, certain basic fundamentals must first be put in place.
In addition to committed and well trained teachers, the education system must be supported by excellent school facilities to nakalah a physically conducive environment for the learning journey. Many olahraa the primary and secondary schools both government and aided in Singapore were some 20 to 30 years old about the pedaoggi when this vision was pedahogi. The pedagogj and upgraded facilities will include computer laboratories, media resource libraries, IT learning resource rooms, IT networking for the entire school, pastoral care rooms and health and fitness rooms.
Teachers and students can also look forward to bigger classrooms and staff-rooms, and more interaction areas. Schools that were built before will either be rebuilt or upgraded. Upgrading works involve construction of extension blocks and alteration of existing school buildings. Rebuilding works involve the construction of entirely new buildings.
Construction in PRIME is carried out in phases, and the selection of schools for PRIME is determined by the age and state of the school physical facilities as well as the availability and suitability of sites for this purpose. Ministry of Education, Singapore at www.
As of Julysome schools have been included in the earlier ten phases of PRIME, of which schools have completed their upgrading programmes. Beginning in earlyall schools will be provided with an indoor sports hall in phases to facilitate flexibility in co-curricular activities, sports and games without being affected by inclement weather Ministry of Education, Given the massive capital investments in PRIME projects, important consideration must be given to budgetary and costs controls.
Part of this important consideration relates to how costs may be better controlled through an effective system for managing change in the design and construction phases of the PRIME projects. Construction projects are bound to encounter change orders; the goal of the owner, design or construction manager is to limit the number of such changes CII, a; Ibbs, Proper management of change orders is very significant for all types of construction projects.
Changes in drawings and contract documents usually lead to a change in contract price or contract schedule. Change also increases the possibility of contractual disputes. Conventionally, changes present problems to all the parties involved in the construction process.
makalah pedagogi olahraga pdf
This is not to say that makalab do not create a slew of problems of their own but that these problems were often compounded by inherent design flaws. If one were to seriously consider olaheaga to reduce problems on site, an obvious place to begin with is to focus on what the project team can do to eliminate these problems at the design phase. There are many reasons for issuing construction change order in the construction process.
It can be pedagoggi result of the non-availability or slow delivery of required materials or the correction of contract document errors and omissions Thomas, Identifying the causes of change orders is very important in order to avoid potential changes in future projects or to minimize their effects.
The construction process is influenced by highly changing variables and unpredictable factors that could result from different sources Zipf, These sources include the performance of construction parties, resources availability, environmental conditions, involvement of other parties and contractual relations. As a consequence of these sources, the construction of projects may face problems which could cause delay in the project completion time Clough and Sears, In the case of time over run, the most important factors that caused delays were design changes, poor labor productivity, inadequate planning and resource shortage.
The impact of changes varies from one project to another.
However, it is generally accepted that the changes affect the construction projects with unpalatable consequences in time and cost CII, ; CII, ; Hester, et al. The nature and frequency pedzgogi changes occurrence vary from one project to another depending on various factors CII, a; Kaming, et al.
PENDIDIKAN JASMANI, OLAHRAGA, DAN BERMAIN | ONOPIRO Weblog
Changes in construction projects can cause substantial adjustment to the contract duration, total direct and indirect costs, or both Tiong, ; Odell, ; Ibbs, a; Ibbs, et al. Therefore, project management teams must have the ability to respond to changes effectively in order to minimize their adverse impact to the project. Great concerns have been expressed in recent years regarding the impact of changes in construction projects.
As mentioned briefly in the previous section, changes are frequent in construction projects and can cause considerable adjustments to the project time, cost and quality. The causes of change orders are greatly varied, thus making the task of change management difficult for most clients. However, the undesirable situation can be minimized as long as a mechanism for handling change orders and making more informed decisions based on the past projects can be understood and built into project management.
The litmus test for successful management should not be whether the project was free of change orders, but rather, if change orders were resolved in a timely manner to the benefit of all the parties and the project.
A clearer view of the causes and their impacts and controls will enable the project team to take advantage of beneficial changes when the opportunity arises without an inordinate fear of negative impacts. No such studies have been undertaken on the management and control of change orders on a large scale so far using an IT based decision support system platform.
The Project Change Management System PCMS will assist professionals in analyzing changes and selecting the appropriate controls for minimizing their adverse impacts by providing timely information. Furthermore, by having a systematic way to manage changes, the efficiency of project work and the likelihood of project success should increase. Learning from the changes is very important because the professionals could improve and apply their experience in the future Ibbs, et al.
In cases where professionals leave the organization, the project experience continues to reside within the individual professionals.
west mata volcano: Topics by
In the absence of an established and organized knowledge-base of past similar projects, the professional teams would face problems in planning effectively before starting a project, during the design phase as well as during the construction phase to minimize and control changes and their effects.
Hence, a comprehensive system for consolidating decisions made on past similar projects is highly recommended. Most researchers have looked at the classification of changes Thomas and Napolitan, ; Yu, ; Fisk, ; Hsieh, et al.
The issue concerning changes has received much attention in the literature. Despite many articles and much discussion in practice and academic literature, an in-depth and holistic view of causes, their effects and controls for changes for making timely and more informed decisions for effective management of change orders was not well represented in the literature. A clearer view of the causes and their impacts on the projects will enable the project team to take advantage of beneficial changes.
Eventually, a clearer and comprehensive view of the causes, their effects and potential controls will result in informed decisions for effective management of change orders. In view of the transfer and acquisition of construction knowledge and experience, a Decision Support System DSS can help to conserve the knowledge and experience and make these more widely, easily and quickly available for assisting in the decision making process Alkass, et al.
The decision aid can also facilitate the knowledge acquisition process once it has acquired the necessary construction knowledge and experience and transferred these into a usable form McCoy and Levary, A knowledge-base would assist in making more informed decisions because it provides an excellent opportunity to learn from past projects Turban, ; Arain and Low, b.
A comprehensive knowledge-base of past projects is recommended. However, there were no significant research studies undertaken on the management and controls of change orders on a large scale so far using an IT based management system platform. Functionally, a change order accomplishes after execution of the agreement what the specifications addenda do prior to bid opening see Figure 1except that an accompanying price change may be involved in a change order. It is the standard practice in construction contracts to allow the owner the right to make changes in the work after the contract has been signed and during the construction period.
To overcome the problems associated with changes to a project, the project team must be able to effectively analyze the change and its immediate and downstream effects CII, a. Potential Causes of Change Orders An effective analysis of changes and change orders requires a comprehensive understanding of the root causes of changes Hester, et al.
Hence, 53 causes of change orders were identified. As shown in Figure 2, the causes of changes were grouped under four categories: Owner related changes, Consultant related changes, Contractor related changes and Other changes.
These groups assisted in developing a comprehensive enumeration of the potential causes of changes. The 16 potential effects identified from the literature review are shown in Figure 3. These will also form the basis for the survey of the professionals described later.
Aufgaben zu Technische Mechanik 1 – 3. Statik zum erfolgreichen Werk ” Technische Mechanik” von Gross/Hauger/Schnell price for United Kingdom ( gross). Buy Technische Mechanik 1: Statik (Springer-Lehrbuch) 13th , ed. by Gross (ISBN: ) from Amazon’s Book Store. Werner Hauger. Buy Technische Mechanik, Band 1: Statik (Springer-Lehrbuch) 11 by Dietmar Gross, Werner Hauger, Jorg Schroder (ISBN: ) from Amazon’s.
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Statik Springer Lehrbuch by Dietmar Gross. Das Buch enthAlt zahlreiche durchgerechnete Beispiele, so dass der Leser Aufgaben und Herleitungen nachvollziehen kann.
Der dargestellte Stoff orientiert sich am Umfang der an deutschsprachigen Hochschulen abgehaltenen Mechanikkurse. Paperbackpages.
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dios es redondo juan villoro | Get Read & Download Ebook dios es redondo juan villoro as PDF for free at The Biggest ebook library in the world. Get dios es. Legal dios es redondo juan villoro eBook for free and you can read online at Online Ebook Library. Get dios es . el libro salvaje juan villoro pdf-7elsjv10 AWS. Results 1 – 30 of 34 DIOS ES REDONDO by VILLORO, JUAN and a great selection of related books, art and collectibles Seller: KALAMO LIBROS, S.L.. (Madrid.
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Dios es Redondo by Juan Villoro. Durante varias decadas, el escritor mexicano se ha ocupado del oficio de patear balones y del delirio colectivo que convoca. Dios es redondo ofrece una vibrante cronica de la religion laica que llena los estadios, las mitologias y supersticiones de un deporte que ocurre en el cesped pero tambien en la mente de los aficionados.
La divertida y muchas veces epica aproximacion literaria de Villoro puede cautivar al forofo deseoso de compartir datos reveladores al calor de una tertulia, pero tambien al curioso -y aun al enemigo del futbol- interesado en conocer las causas que llevan a proferir alaridos en nombre de un equipo.
Enviado especial a los mundiales de Italia 90 y Francia 98, Villoro domina el arte de escribir al borde de la cancha, pero tambien el tono reflexivo. El ensayista de Efectos personales Anagrama, sabe que los grandes goles duran toda la vida y definen los destinos de quienes los presenciaron.
Dios es redondo rinde tributo al mas colorido de los divos del pie privilegiado, Diego Armando Maradona, registra las glorias y los excesos de la liga espanola, ofrece indelebles estampas del ultimo Mundial del siglo XX y brinda un notable ejemplo del arte de la conversacion con Jorge Valdano. El pulso del novelista de El testigo Anagrama, entronca en estas paginas con el ritmo tenso del cronista, dispuesto a atrapar la vida secreta de los goles, las razones que eternizan lo que ocurre en un instante.
Published May 29th by Planeta first published April To see what your friends thought of this book, please sign up. To ask other readers questions about Dios es Redondoplease sign up. Lists with This Book. Jan 07, Samuel Ch. El futbol es la venganza del pie sobre la mano, y este libro es su decreto.
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View all 3 comments. Jan 20, Joshua Romero rated it really liked it. Villoro logra expresar lo que sentimos todos los amantes del futbol, un deporte de grandes.
Jan 21, Elyse Hdez rated it really liked it. Villoro lo hizo de nuevo. Maybe it’s the English translation, but I did not find this a particularly intelligent book. No real structure or insight, just a collection of musings by someone who ‘s been on the scene for a while. This is another punchy and simplistic sports book by an author who has little faith in his readers and doesn’t even attempt to treat sports writing like serious non-fiction.
Also, heed the title and summaries of this book It’s entir Maybe it’s the English translation, but I did not find this a particularly intelligent book.
That’s not a criticism exactly But lovers of the game itself, not just the culture, will not be satisfied with this book.
You are probably familiar with this famous Garry Lineker apothegm: Twenty-two men chase a ball for ninety minutes and at the end, the Germans always wins.
However, we kno You are probably familiar with this famous Garry Lineker apothegm: But is it as fun?
Yet, if you care ess facticity, well, good luck. You know the sides. Increasingly, our football experiences seem confined to either of these reductive camps or types. But does it have to be?
Learning German is work enough. Treading between myth and history, Villoro establishes the premise that footballing success requires prior tragedy, that is, something to galvanize and to add urgency to those 90 minutes. The Dutch were clean.
Too clean for success, according to Villoro. Sticking with German football-related examples, this method redono Villoro frequently to make surprising discoveries, such as listing Wolfgang Overath as the only Se representative in his chapter of famous Number 10s. God Is Round is allusive in such a way that nestles football nay, sport itself into the heart of our most significant cultural expressions.
Something we must have. Yet because football itself provides its own epics, narratives, tragedies, heroes, and villains, the football writer is a reiterator, working with material that already is.
Incomprehensibility forms the foundational thematic thread in God Is Round. Of course, in another register football libfo plenty of quantifiable events and results. As such, we bear witness to football and respond to it in fandom, of which writing itself is a type.
Of course, Villoro explains that this is an idealized childhood we elect to remember, not one we actually lived through. Nonetheless, the childlike experience of mystery, wonderment, and most importantly, confronting the incomprehensible, is what gives football meaning, according to Villoro. Hence, as Villoro indirectly gestures, our admiration for Diego Maradona and Leo Messi, whom the Mexican writer captures wonderfully in two portrait essays attempting to interpret the significance of these footballing giants.
God Is Round is worth its price tag for these two essays alone, which will become required reading for the thinking football fan. However, what this antidote looks like in practice is hard to picture, given the impossibility of restoring a pre-globalization and pre-professionalization version of football, as Villoro himself concedes. Football has left is working class roots as a relief from industrialization far behind.
Yet he is not deterred, citing — of all things — the Champions League final as an example of the football itself on the pitch being the one stable thing i. We are crazy for this game.
Chock-a-block with great anecdotes, dazzling quotes, and characters who can only come from the world of football. Essential World Cup Reading. I will refer to the sport as both soccer and football, the other football having no place here. This book name comes from a true love for the game, and its author, Juan Villoro, is an encyclopedia of the sport — and also of literature. Nor do I know all of the players — but even a non-follower must recognize more of these legends than they might think.
Football is present in every part of life — Juan Villoro writes this into being. He riffs on the importance of television, radio, and stadiums — any means of connecting the fans to the game — but dils the outsized hold of t. He also has a few things to say about how advertisement and sponsorship are ruining the game.
I learned of the origins of and changes to jersey numbers, and following a chapter on some of the great number 10s, the most lengthy continuous topic is a biography of Diego Armando Maradona, highlighting the contrasts between his life in the game and his excesses off the pitch.
Both are out of touch, based both on ego and skill, the first so much so that no one else can use his name despite all this confusion and another player, Ronaldinho, is named thusly. I like how he and his countrymen are described as playing at a samba-like pace.
Villoro knows every nickname, and has alternative titles for every person, place, ez or redoondo. For more reviews, follow my blog at http: De pronto, Zidane encuentra un hueco y enfila hacia la nada. Lo invisible es la certeza que nos consta. Solo cuando se abren, las heridas entregan sus lecciones.
Dios es Redondo by Juan Villoro
I always enjoy these kinds of books: This one, written by a Mexican author and translated from Spanish, was another good one. One example of a turn of phrase that I particularly enjoyed about Maradona: A lapidary collection of belles lettres on futbol, rich in anecdote and rumination. Villoro cites a plethora of authors: Villoro manages to skate around preciousness because of his passion for the game and his sense of humor; at no point does he present himself as Eric Idle’s interviewer in the Jimmy Buzzard sketch: The book really kicks into high gear towards the end, A lapidary collection of belles lettres on futbol, rich in anecdote and rumination.
He concludes with a scathing indictment of FIFA. It’s hard to think of a similar collection of linked essays on baseball. Roger Angell might have been able to do it, had he been born 40 years later than he was. This is a collection of elegant, passionate, essays about the world’s most popular sport: Villoro is a well know Mexican novelist and playwright.
He is also a passionate fan. His writing helped me understand the mania that takes over the rest of the world every weekend. This was particularly interesting for me because most of my soccer interest is Euro-centric.
Villoro writes about the great players of Europe but also about following small, unsuccessful clubs in South America as This is a collection of elegant, passionate, essays about the world’s most popular sport: Villoro writes about the great players of Europe but also about following small, unsuccessful clubs in South America as well as a Mexican national team then never seems to peak at the right time. Often I could not follow him because the events and players were so foreign to me.
I love his explanation of the best players ever and what made them so special. I usually only read this kind of sportswriting when it is centered on baseball. This historically based, utterly irrational, anecdote-laden football fandom is new to me.
Olivier Messiaen wrote several orchestral works while still in his early twenties, and the pair of those compositions included here offers fascinating glimpses of a . Olivier Messiaen instructs in the score to Et exspecto resurrectionem mortuorum, which was commissioned by French Minister of Cultural Affairs. For Et exspecto resurrectionem mortuorum means “In expectation of the resurrection of the dead”. It’s not meant to be oppressive or gloomy.
Tanglewood Program Notes: Messiaen, Et Exspecto Resurrectionem Mortuourum
Et exspecto resurrectionem mortuorum And I await the resurrection of the dead is a work for wind orchestra by Olivier Messiaenwritten in and first performed the following year. It is composed in five movements.
Originally envisioned as a work for chorus, large orchestra and brass, to be performed in June at resurrectiomem Sainte-Chapelle in Paris and at Notre-Dame de Chartresthe concept of the work and projected date of performance changed several times over the following year. It was premiered in the Sainte-Chapelle at The piece was destined to be performed in large spaces like churches, cathedrals and the open air.
Messiaen was inspired by the countryside which surrounded him as he worked on the composition — the Hautes-Alpes with their great mountains — but also the imposing images of Gothic and Romanesque churches, and the ancient monuments of Mexico and Ancient Egypt. The piece is scored for woodwind, brass and percussion sections.
The string section of a symphony orchestra is omitted entirely. Originally issued on LP, From Wikipedia, the free encyclopedia. Authority control MusicBrainz work: Claire Delbos first wife Yvonne Loriod second wife.
Olivier Messiaen – Et Exspecto Resurrectionem Mortuorum () – Music Sales Classical
La jeune France Modes of limited transposition Ondes Martenot. List of compositions by Olivier Messiaen.
Retrieved from ” https: Compositions by Olivier Messiaen compositions Concert band pieces. All articles with unsourced statements Articles with unsourced statements from December Wikipedia articles with MusicBrainz work identifiers. reurrectionem